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Sildenafil is really a potent and selective inhibitor of cGMP-unique phosphodiesterase kind 5 (PDE5), that's chargeable for degradation of cGMP within the corpus cavernosum. The molecular construction of sildenafil is similar to that of cGMP and acts to be a aggressive binding agent of PDE5 during the corpus cavernosum, causing far more cGMP and en